The Human Phenotype Project
About Project 10K
A long-term observational study designed to predict disease years before it appears, combining medicine, biology and computer science.
Who we are
A study by the Weizmann Institute
Project 10K is run by a multidisciplinary team of scientists and physicians combining medicine, biology and computer science — including researchers behind breakthroughs such as the gut microbiome's role in personalized nutrition and disease.
We follow thousands of participants in Israel over many years, collecting deep data on lifestyle, body and health — looking for the earliest signals that link everyday exposures (diet, sleep, activity, microbiome) to the onset of disease.
By the numbers
A decade of deep data
Since 2014, across thousands of participants in Israel.
Our goal
Predict disease before it appears
To develop methods that predict disease years before it breaks out — shifting medicine from treatment toward prevention, personalized to each individual.
A study by the Weizmann Institute of Science, combining medicine, biology and computer science.
Our method
The science behind 10K
From thousands of measurements to the earliest signals of disease.
- Deep phenotyping
Thousands of measurements per person — blood, genetics, gut microbiome, imaging, sleep and more.
- AI models
Machine-learning models surface the patterns across this data that humans can't see.
- Predict early
Detect the earliest signals of disease, often years before symptoms appear.
Publications
Research & publications
A decade of peer-reviewed research, 2014–2025, in journals including Nature Medicine and Nature Metabolism. Prof. Eran Segal is a co-author on every paper.
Read the published research →The team
The research team
Researchers, physicians and data scientists behind the study, conducted at and in partnership with the Weizmann Institute of Science.
Leads the study and is a co-author on every paper in its published archive.
Dr. Smadar Shilo 
Dr. Adina Weinberger 
Dr. Ori Cohen Dr. Yeela Talmor 
Dr. Tal Ofek Nastya Godneva 
Yuval Brodsky Hila Saranga Hagai Rossman Maya Lotan David Weinberg Rotem Shaulitch Noa Dolev Tali Paz Lisa Shusterman Tali Davidson Miri Klein Orit Kolker Ella Harpaz Anna Panik Michal Tsigalnitski Yana Metel Alla Freilakhman Karin Shannon Michal Rozenfeld 