For researchers
Cohort profile & methodology
How the cohort is built and measured: a deeply-phenotyped, longitudinal study of thousands of participants, characterised across clinical, molecular, imaging and behavioural domains at every visit.
The cohort at a glance
Headline figures from the study to date.
- 6,269men
- 7,231women
- 55,000questionnaires
- 137,000glucose-sensor days
- 1,912,817blood tests
Data modalities
Each participant contributes thousands of measurements across these domains, repeated over the follow-up.
- Clinical visits
Standardised in-person assessments and physical measurements at each follow-up.
- Questionnaires
Lifestyle, diet, medical history and well-being surveys collected over time.
- Blood & biomarkers
Comprehensive blood panels, metabolomics and other molecular assays.
- Gut microbiome
Metagenomic sequencing of stool samples for microbial composition and function.
- Continuous glucose
CGM monitoring capturing real-world glycaemic response over multiple days.
- Imaging
Body composition, cardiac and other imaging modalities per protocol.
- Sleep & activity
Wearable-derived sleep, heart rate and physical activity records.
- Anthropometrics
Repeated body measurements tracked across the longitudinal follow-up.
The first-visit protocol
A standardised battery of measurements at the baseline visit, followed by two at-home kits.
- Blood pressure
- Weight, height & circumferences
- Liver & carotid ultrasound
- ABI (ankle–brachial index)
- Blood & DNA sample
- DEXA (bone density & body composition)
- ECG
- Two-week lifestyle logging (app)
- Hand-grip strength
- Retinal fundus imaging
- LiteBC
- Voice test
- Vaginal microbiome (women only)
Metagenomic sampling for the gut microbiome, done at home and couriered back.
A multi-night home sleep study screening for sleep apnea.
Explore the science
See the peer-reviewed research built on this cohort, or get in touch about access and collaboration.